ACE2 and COVID 19
This article describes the life cycle of Coronavirus (COVID-19) in six simple steps. It also discusses the role of spike (S) protein of the SARS-CoV-2 virus and the role of Angiotensin-converting enzyme 2 (ACE2) receptors of the host cell in spreading the viruses. This understanding can help to develop suitable drugs and antibodies to counter the viruses.
How the Virus Spread
Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) spreads primarily through droplets (respiratory secretions) and close person-to-person contact. When a person talks, coughs or sneezes, there are droplets. These droplets spread the virus. It also spreads when a person touches a surface or object that has the virus on it, then touches their eyes, nose, or mouth. Study found that people touched surfaces and their mouth or nose 3 to 4 times per hour. Hence, hand washing is really vital to stop coronavirus.
Life Cycle of COVID-19 (SAS-CoV-2)
After the virus enters into the body, it binds to primary target cells that express abundant virus receptor, the angiotensin-converting enzyme 2 (ACE2), including pneumocytes and enterocytes in the respiratory system, lung, intestine, kidney, and blood vessels. The virus enters and replicates in these cells. The matured virions are then released to infect new target cells.… Read more..