glymphatic system

The human brain is a highly complex organ where various fluids play essential roles in maintaining its functions, from nutrient delivery to waste clearance. Among these, Cerebrospinal Fluid (CSF), Interstitial Fluid (ISF), and Cerebral Blood Flow (CBF) are critical components that directly impact brain health and cognitive performance. These fluids interact dynamically, influencing each other’s behavior in ways that are crucial for brain function, especially in terms of metabolic activity, waste removal, and nutrient exchange.

In recent years, computational models have become an indispensable tool for understanding the intricate dynamics of these brain fluids. These models allow researchers to simulate and predict how these fluids behave under various physiological and pathological conditions. This article explores into the computational models used to describe the dynamics of CBF, CSF, and ISF, explaining their interactions and the methods used to study their behavior.

In our, Sri Amit Ray Compassionate AI Lab we have made several computational brain fluid dynamics models, encompassing cerebrospinal fluid (CSF), interstitial fluid (ISF), and cerebral blood flow (CBF). These models focused to integrate the interplay between the brain fluids in maintaining optimum brain health and functionality. By simulating fluid exchange, clearance mechanisms, and vascular dynamics, the research aims to deepen our understanding of neurological disorders like Alzheimer’s disease and hydrocephalus. This work exemplifies the lab’s mission of leveraging AI, and mathematical models to advance neuroscience for compassionate healthcare solutions.