In the present state, the key medicines for COVID-19 viruses are remdesivir, favipiravir, hydroxychloroquine, dexamethasone, coronil and swasar. The total number of coronavirus cases across the world has now crossed the 8-million mark. Meanwhile, major research institutes and pharmaceutical companies are rushing to find a successful vaccine. They are conducting many double-blind, randomized, placebo-controlled clinical trials across the world. Here, we reviewed the status of effectiveness of these medicines against the COVID-19.