Here, we discussed the scopes and implementation issues of artificial intelligence and blockchain for precision medicine. Evidence-based medicine is gradually shifting from therapy to prevention and towards individually tailored precision medicine systems. Where, artificial intelligence can be used to automatically detect problems and threats to patient safety, such as patterns of sub-optimal care or outbreaks of hospital-acquired illness. Artificial intelligence can be used to prevent the issues like drug-interaction, over-diagnosis, over-treatment and under-treatment. It can be used more effectively to solve the problems of antibiotic resistant bacteria.